Sun, 01/26/2025 - 15:40

January 1, 2025

Acetaminophen (e.g., Tylenol, Paracetamol) is the number one cause of acute liver failure in the USA, Canada, and UK. Exceeding 3,250 mg to 3,900 mg (depending on the type and strength) per day can cause liver harm. Acute liver failure can happen after one very large dose of acetaminophen, or after higher than recommended doses every day for several days. Curcumin, a major bioactive compound in turmeric herb, is known for its anti-inflammatory and antioxidant activity, which helps protect tissues and organs. Curcumin is well-recognized for its hepatoprotective activity, which was emphasized using different in vivo hepatic injury and hepatic carcinoma models such as alcohol-induced hepatic fibrosis, aflatoxin-induced liver injury heavy metals-induced liver damage, and paracetamol (Para) induced liver toxicity.