Cinnamon Bark essential oil (Cinnamomum verum) : in vitro investigation of anti-cholinesterase, anti-BACE1, and neuroprotective activity

Wed, 01/01/2025 - 22:27

Alzheimer’s disease (AD) is a chronic neurodegenerative disorder that has been recognized as the key cause of dementia in elderly people. According to the latest data from Centers for Disease Control and Prevention (CDC), 121,499 people died due to AD in 2019. Currently, there is no definite cure for the treatment of AD due to its multi-factorial nature. Therefore, phytotherapy  profiting from valuable biological activities of a mixture of constituents has been in the center of attention. Focusing on the herbal remedies used in the treatment of AD , essential oils (EOs) were found to be very effective since various in vitro, in vivo, and clinical trials have endorsed their efficacy because of low molecular weight and high hydrophobicity leading to easy crossing the blood-brain barrier (BBB).

Essential Oils are naturally occurring secondary metabolites which contain a complex mixture of volatile compounds possessing a wide range of biological activities. It should be noted that aromatherapy using plants such as Cinnamomum verum J. Presl. (Lauraceae), Myrtus communis L. (Myrtaceae), Ruta graveolens L. (Rutaaceae), Anethum graveolens L. (Apiaceae), Myristica fragrans Houtt. (Myristicaceae), and Crocussativus L. (Iridaceae) has been traditionally recommended for the treatment of memory loss in Iranian traditional medicine (ITM). On the other hand, non-pharmacological approaches have been developed for the improvement of cognitive problems and in this respect, aromatherapy has been widely considered as a strong tool. In different studies, the combination of therapies has depicted significant results in improving memory, quality of life, and treatment of other complications in patients with AD.

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Anxiolytic-like Effect of Inhaled Cinnamon Essential Oil

February 11, 2023

Aromatherapy has been one of the most common complementary and alternative treatments for psychological diseases, such as sleep disorders, anxiety, and depression. Essential oils have high efficacy with fewer side effects as compared to conventional drugs. However, the underlying mechanisms that mediate the beneficial effects of essential oils in the treatment of psychiatric disorders remain to be elucidated.

Anxiety is one of the most common mental disorders and is characterized by excessive and uncontrollable nervousness and fear. Typical subtypes of anxiety include generalized anxiety disorder, obsessive-compulsive disorder, post-traumatic stress disorder, social anxiety disorder, panic disorder (with or without agoraphobia comorbidity), and phobias. The first-line medications for most anxiety subtypes are selective serotonin (5-HT) reuptake inhibitors (SSRIs), including paroxetine, sertraline, citalopram, escitalopram, fluvoxamine, and fluoxetine. However, the long-term use of these SSRIs is associated with various adverse effects, such as bleeding, digestive problems, hyponatremia, excessive sweating, emotional blunting, and increased risk of suicidality.

THE SECRETS OF CINNAMON BARK: CHEMICAL FOCUS

October 10, 2017

With a scent reminiscent of an apple pie fresh out of the oven, cinnamon bark essential oil has a familiar and comforting scent that makes it a favorite of aromatherapists. Cinnamon bark is made up of several constituents, including eugenol, and its’ most active ingredient, cinnamaldehyde. These two constituents are primarily responsible for many of the health and beauty benefits cinnamon bark oil has to offer. Here’s a quick look at some of its top benefits.