August 30, 2021
Several representatives of the Coronaviridae family circulate in the human community and typically induce moderate respiratory illness (Corman et al., 2019). In comparison, severe acute respiratory coronavirus syndrome (SARS-CoV) and Middle East respiratory coronavirus syndrome (MERS CoV) are introduced from animals to humans and lead to serious respiratory diseases in affected persons, SARS and MERS, respectively.
Cinnamon has been utilized to remedy a lot of afflictions of humans since it possesses numerous biological activities. In the present research, Cinnamon have been chosen as a potent source of antiviral agents. This study is intended to recognize the phytoderived antiviral substances from Cinnamon against COVID-19 main protease enzyme and to understand the in silico molecular basis of its activity. Cinnamon is a traditional Indian medicine which is being used from hundreds of year to relieve various lung-related disorders includes pneumonia, infectious disease, as well as malignant pleural effusion Recently, several studies also provided scientific data to support and unveil its antiparasitic, antihypertensive, antidiabetic, anti-hyperlipedimic, anti-oxidant, anti-inflammatory, analgesic, antimicrobial, antiviral, antitumor, anti-hypertension, anti-hyperlipemic, gastro-protective and immunomodulation activities. Based on the above properties of Cinnamon, this research aimed to show a variety of active compounds across all Cinnamon varities and decide whether and how they interact with proteins i.e. main protease and spike protein, that are essential in the management of SARS-CoV-2.
Utilizing contemporary strategies, these phyto-compounds from a natural origin might establish a reliable medication or support lead identification. Identified hit compounds can be further taken for in vitro and in vivo studies to examine their effectiveness versus COVID-19